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Association between growth differentiation factor-15 and chronic heart failure in coronary atherosclerosis patients

Z D Zhu1, T Sun2

  • 1Division of Cardiology, Huashan Hospital of Fudan University, Shanghai, China.

Genetics and Molecular Research : GMR
|April 14, 2015
PubMed

Insights

Plasma growth differentiation factor 15 (GDF-15) is elevated in patients with chronic heart failure (CHF) and coronary heart disease. GDF-15 and NT-proBNP show potential as biomarkers for CHF in this population.

Area of Science:

  • Cardiology
  • Biomarkers
  • Heart Failure Research

Background:

  • Coronary heart disease (CHD) is a leading cause of morbidity and mortality.
  • Chronic heart failure (CHF) is a common complication of CHD.
  • Identifying reliable biomarkers for CHF in CHD patients is crucial for timely diagnosis and management.

Purpose of the Study:

  • To investigate the association between plasma growth differentiation factor 15 (GDF-15) levels and the presence of CHF in patients with coronary atherosclerosis.
  • To compare GDF-15 levels with N-terminal pro-B-type natriuretic peptide (NT-proBNP), another established heart failure biomarker.
  • To evaluate the diagnostic performance of GDF-15 and NT-proBNP in identifying CHF.

Main Methods:

  • Plasma GDF-15 and NT-proBNP levels were measured in 269 untreated coronary atherosclerosis patients (98 with CHF, 84 without CHF, 87 controls) using ELISA.
  • Echocardiography was performed to assess left ventricular ejection fraction (LVEF).
  • New York Heart Association (NYHA) functional classification was used to subgroup CHF patients.

Main Results:

  • Plasma GDF-15 levels were significantly higher in coronary atherosclerosis patients with CHF compared to those without CHF and controls (P < 0.05).
  • NT-proBNP levels exhibited a similar trend to GDF-15.
  • GDF-15 levels were positively correlated with NT-proBNP (r = 0.861) and negatively correlated with LVEF (r = -0.936).
  • Receiver operating characteristic (ROC) curve analysis showed areas under the curve of 0.804 for GDF-15 and 0.795 for NT-proBNP.

Conclusions:

  • Plasma GDF-15 is significantly associated with CHF in patients with coronary atherosclerosis.
  • GDF-15 demonstrates potential as a valuable biomarker for diagnosing CHF in this patient group, comparable to NT-proBNP.
  • Combined assessment of GDF-15 and NT-proBNP may aid in the management of CHF in coronary atherosclerosis patients.

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