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Published on: September 20, 2018
Clinical manifestations of patients with CASPR2 antibodies
Jun-Sang Sunwoo1, Soon-Tae Lee1, Jung-Ick Byun1
1Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Korea Autoimmune Synaptic and Paraneoplastic Encephalitis Registry (KASPER), Seoul, South Korea.
Abstract:
Contactin-associated protein-like 2 (CASPR2) is one of the target antigens of voltage-gated potassium channels (VGKC) complex antibodies. There has been relatively little information in the literature regarding CASPR2 autoimmunity, especially in Asian population. We investigated the presence of CASPR2 antibodies in patients with presumed autoimmune neurological disorders and described the clinical features, laboratory findings, and responses to immunotherapy. Five patients were identified to be positive for CASPR2 antibodies. The results obtained here suggested that CASPR2 antibodies might be the possible cause of epilepsy even in the absence of typical features of limbic encephalitis and that immunotherapy could provide a favorable outcome.
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