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Effect of sepsis on behavioral changes on the ketamine-induced animal model of schizophrenia
Clarissa M Comim1, Napoleão C Silva2, Janini J Patrício1
1Laboratory of Neuropathology, Postgraduate Program in Health Sciences, University of South Santa Catarina, Palhoça, SC, Brazil.
Abstract:
This study aimed to evaluate the effect of sepsis on behavioral changes on the ketamine-induced animal model of schizophrenia. Male Wistar rats underwent Cecal Ligation and Perporation (CLP) with "basic support" or were sham-operated. After 30 days, the animals were submitted to a model of schizophrenia by injection of Ketamine. The behavior tests were performed after 30 min of the injection of Ketamine or saline. Ketamine in doses of 15 and 25mg/kg increased locomotor activity, latency to first contact in the social interaction and stereotyped behavior. Some changes caused by sepsis may be associated with a predisposition to develop schizophrenia in the animal model.
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