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Biphenotypic B-cell lymphoma in 2 cats.
Liana Granum1, Elena Gorman1, Craig Ruaux1
1College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA.
Veterinary Clinical Pathology
|April 14, 2015
Summary
This study reports the first known case of biphenotypic lymphoma in cats, a rare cancer expressing both B- and T-cell markers. The aggressive nature of this feline lymphoma suggests a poor prognosis.
Area of Science:
- Veterinary Pathology
- Oncology
- Immunology
Background:
- B-cell lymphoma is a common malignancy in felines.
- Biphenotypic lymphomas, expressing markers of multiple lymphoid lineages, are rare in animals.
Observation:
- Two cats presented with distinct clinical signs, including cutaneous masses and lethargy due to kidney infiltration.
- Cytology and histopathology revealed round cell neoplasia.
- Immunohistochemistry confirmed neoplastic cells expressed both B- and T-lymphocyte markers.
Findings:
- PCR analysis demonstrated clonal B-cell receptor gene rearrangement and polyclonal T-cell receptor gene rearrangement.
- The lymphomas were diagnosed as B-cell lymphoma with aberrant CD3 expression.
- Both cases showed rapid disease progression, indicating a poor prognosis for this feline lymphoma type.
Implications:
- This is the first documented report of true biphenotypic lymphoma in cats.
- Understanding this rare lymphoma subtype is crucial for accurate diagnosis and treatment strategies in feline oncology.
- Aberrant marker expression in feline lymphoma warrants further investigation.
