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Twin screw wet granulation: Binder delivery.

Mohammed F Saleh1, Ranjit M Dhenge1, James J Cartwright2

  • 1Department of Chemical and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.

International Journal of Pharmaceutics
|April 15, 2015
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Summary

Incorporating solid binder with powder mixture in twin screw granulation (TSG) improves granule properties and binder distribution. This method enhances residence time, torque, and produces more spherical granules compared to other binder delivery methods.

Keywords:
Granule propertiesOnline binder distributionPIVTwin screwWet granulation

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Area of Science:

  • Pharmaceutical Technology
  • Chemical Engineering
  • Materials Science

Background:

  • Twin screw granulation (TSG) is a widely used process for producing granules with desired properties.
  • Binder delivery method significantly influences granulation outcomes, including granule characteristics and process parameters.
  • Understanding binder distribution and granule dynamics is crucial for process optimization.

Purpose of the Study:

  • To investigate the impact of three distinct binder delivery methods on twin screw granulation.
  • To analyze the effects on residence time, torque, granule properties (size, shape, strength), and binder distribution.
  • To evaluate the influence of screw configuration and binder delivery on granule surface velocity.

Main Methods:

  • Utilized high-speed imaging and offline techniques for binder distribution analysis.
  • Employed particle image velocimetry (PIV) to study granule surface velocity.
  • Varied binder delivery: all solid, 50% solid/50% liquid, and all liquid.
  • Modified screw configurations: conveying elements only vs. conveying with kneading elements.

Main Results:

  • Incorporating all solid binder with powder mixture led to longer residence time, higher torque, and narrower granule size distribution.
  • This method also resulted in more spherical granules, with smaller granules being stronger and larger ones weaker.
  • Better binder distribution was observed with the all-solid binder incorporation method.
  • Granule surface velocity varied across screw channels and decreased with the addition of kneading elements.

Conclusions:

  • The method of binder incorporation significantly impacts twin screw granulation performance and granule attributes.
  • All-solid binder incorporation offers advantages in terms of process control and granule quality.
  • Screw configuration, particularly the inclusion of kneading elements, affects granule movement and distribution within the granulator.