Related Experiment Video
Updated: Apr 15, 2026
Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Serum omentin levels predicts mesenteric ischemia
Background:
Acute mesenteric ischemia (AMI) is an intestinal vascular disease with high mortality. Clinical diagnosis of acute mesenteric ischemia is difficult. Adipose tissue is an important mediator of metabolism and inflammation.Omentin is produced by visceral adipose tissue and decreased serum levels of omentin are associated with poor metabolic outcomes. We aimed to investigate whether serum omentin level predicts early diagnosis of AMI before development of transmural ischemia.
Methods:
Twenty-four Sprague Dawley rats weighted about 200-250 gr grouped in 3 experimental groups as sham, transient ischemia and permanent ischemia. Each group consisted of 8 rats. Blood samples were evaluated to determine serum urea, creatinine, omentin and C-reactive protein (CRP) levels. A blinded histological examination performed with the same histologist for hemotoxileneosine painted ileal tissue samples.
Results:
Mean serum omentin level in sham group (27.5±4.67) was significantly elevated compared to rats in Ischemia-reperfusion (IR) group (10.9±9.01).The difference reached the statistical significance (p=0.004). Serum omentin levels were not correlated to urea, creatinine or CRPlevels.
Conclusion:
Omentin levels may be a biochemical indicator to detect AMI. However, further human studies are needed (Tab. 3, Fig. 3, Ref. 34).
Insights
Serum omentin levels may help diagnose acute mesenteric ischemia (AMI) early. Lower omentin levels were observed in rats with AMI, suggesting its potential as a diagnostic biomarker.
Area of Science:
- Vascular Surgery
- Gastroenterology
- Metabolic Research
Background:
- Acute mesenteric ischemia (AMI) presents diagnostic challenges and high mortality.
- Omentin, a visceral adipose tissue protein, is linked to metabolic health.
- Decreased serum omentin correlates with adverse metabolic outcomes.
Purpose of the Study:
- To investigate if serum omentin levels can predict early AMI.
- To assess omentin's role before transmural ischemia develops.
Main Methods:
- A rat model with sham, transient ischemia, and permanent ischemia groups (n=8 each).
- Serum analysis for urea, creatinine, omentin, and C-reactive protein (CRP).
- Histological examination of ileal tissue.
Main Results:
- Serum omentin levels were significantly lower in the ischemia-reperfusion group compared to the sham group (p=0.004).
- No correlation was found between serum omentin and urea, creatinine, or CRP levels.
Conclusions:
- Serum omentin may serve as a potential biochemical marker for early AMI detection.
- Further clinical studies in humans are required to validate these findings.
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