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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Chronic kidney disease as a risk factor for incident gout among men and women: retrospective cohort study using data

Weiqi Wang1, Vidula Manish Bhole2, Eswar Krishnan1

  • 1Stanford University School of Medicine, Palo Alto, California, USA.

BMJ Open
|April 15, 2015
PubMed

Insights

Chronic kidney disease (CKD) is an independent risk factor for developing gout. Individuals with CKD have a significantly higher incidence of gout, underscoring the link between kidney health and this inflammatory arthritis.

Area of Science:

  • Nephrology
  • Rheumatology
  • Epidemiology

Background:

  • The relationship between chronic kidney disease (CKD) and gouty arthritis has historically been poorly understood.
  • Investigating this association is crucial for understanding gout pathogenesis and patient risk stratification.

Purpose of the Study:

  • To determine if CKD is an independent risk factor for incident gout.
  • To quantify the risk of developing gout in individuals with CKD.

Main Methods:

  • Analysis of data from the Framingham Heart Study cohort (2159 men, 2558 women) from 1948-2002.
  • Cox proportional hazard models were used to estimate hazard ratios (HR) for incident gout associated with CKD.
  • Adjustments were made for age, alcohol consumption, smoking, hypertension, diabetes, and body mass index.

Main Results:

  • Over 140,421 person-years, 371 incident gout cases were identified.
  • Gout incidence was higher in participants with CKD (6.82 per 1000 person-years) compared to those without (2.43 per 1000 person-years).
  • CKD was associated with increased gout risk in both men (HR 1.88) and women (HR 2.31), independent of other risk factors.

Conclusions:

  • The study provides robust epidemiological evidence that CKD is a significant risk factor for developing gout.
  • These findings highlight the importance of considering kidney function in the assessment and management of patients at risk for gout.
Abstract

Keywords:
EPIDEMIOLOGYSTATISTICS & RESEARCH METHODS

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