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Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
Published on: July 14, 2015
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A poly(alkyl methacrylate-divinylbenzene-vinylbenzyl trimethylammonium chloride) monolithic column for solid-phase
Wan-Ling Liu1, Stephen Lirio1, Yicong Yang2
1Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, Chung-Li 320, Taiwan.
Journal of Chromatography. A
|April 15, 2015
Summary
New organic polymer monolithic columns effectively extract non-steroidal anti-inflammatory drugs (NSAIDs) using solid-phase microextraction (SPME). Poly(BMA-DVB-VBTA) columns offer repeatable, reusable extraction of NSAIDs from river water.
Area of Science:
- Analytical Chemistry
- Materials Science
- Environmental Science
Background:
- Solid-phase microextraction (SPME) is a crucial technique for analyzing trace contaminants.
- Developing novel adsorbent materials is essential for improving SPME efficiency and reusability.
- Non-steroidal anti-inflammatory drugs (NSAIDs) are common environmental pollutants requiring sensitive detection methods.
Purpose of the Study:
- To develop and optimize organic polymer monolithic columns for the solid-phase microextraction (SPME) of non-steroidal anti-inflammatory drugs (NSAIDs).
- To investigate the effect of monomer composition, particularly the alkyl chain length of methacrylate esters, on extraction efficiency.
- To evaluate the reusability and application of the developed monolithic columns for NSAID determination in real water samples.
Main Methods:
- In situ polymerization of alkyl methacrylate-ester (AMA), divinylbenzene (DVB), and vinylbenzyl trimethylammonium chloride (VBTA) to create monolithic columns.
- Optimization of SPME parameters including monomer ratio, column length, sample pH, flow rate, and desorption solvent.
- Evaluation of column permeability using poly(ethylene glycol) (PEG) as a porogenic solvent.
- Analysis of NSAID recovery and repeatability using gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-mass spectrometry (LC-MS) (implicit).
Main Results:
- Decreasing the alkyl chain length of AMA (e.g., poly(BMA-DVB-VBTA)) enhanced the extraction efficiency for several NSAIDs.
- The poly(BMA-DVB-VBTA) monolithic column demonstrated high repeatability (RSD < 6.8%) and recovery rates (85.0–100.2%) for NSAIDs.
- The poly(BMA-DVB-VBTA) column maintained extraction efficiency after at least 50 reuse cycles.
- Trace-level NSAIDs in river water samples were successfully extracted with good recoveries (75.8–90.8%) using the optimized poly(BMA-DVB-VBTA) column.
Conclusions:
- Organic polymer monolithic columns, particularly poly(BMA-DVB-VBTA), are effective adsorbents for SPME of NSAIDs.
- The developed SPME method offers high repeatability, reusability, and applicability to environmental water samples.
- This approach provides a promising tool for the sensitive determination of NSAIDs in complex matrices.
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