Related Experiment Video
Updated: Apr 15, 2026

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
Published on: March 25, 2020
Cholesterol, statins, and dementia: what the cardiologist should know
Brett L Wanamaker1, Kristopher J Swiger, Roger S Blumenthal
1Department of Medicine, Division of Cardiology, The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, Maryland.
None:
Alzheimer dementia (AD) is an important clinical problem that appears to be closely tied to comorbid cardiovascular disease, making it a relevant topic for the clinical cardiologist. Determinants of cardiovascular health, especially midlife dyslipidemia, are associated with an increased risk of dementia based on molecular and epidemiologic data. Given the potential role of dyslipidemia in the development of dementia, statins have been investigated as potential therapeutic options to slow or prevent disease. This review discusses the role of dyslipidemia and other cardiovascular risk factors in the pathogenesis of AD, with a focus on the existing evidence for the use of statin medications in the treatment and prevention of AD from observational studies and randomized clinical trials. Clinical questions for the practicing cardiologist are addressed.
Related Concept Videos
Dementia
The progression of dementia is generally gradual....
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Alzheimer's Disease: Treatment
Cholesterol: Significance and Regulation
Considering cholesterol and...
Atherosclerosis III: Management
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
