Antimalarial activity of tulathromycin in a murine model of malaria
Nicolas Villarino1, Joshua E Denny2, Nathan W Schmidt3
1Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.
Abstract:
There is an urgent need for new antimalarial agents and strategies to treat and control malaria. This study shows an antiplasmodium effect of tulathromycin in mice infected with Plasmodium yoelii. The administration of tulathromycin around the time of infection prevented the progression of disease in 100% of the animals. In addition, highly parasitized mice treated with tulathromycin showed a decreased parasite burden and cleared the parasite faster than did untreated infected mice.
