Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.9K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.9K
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

910
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
910
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

3.0K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
3.0K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

603
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
603
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

1.2K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.2K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

2.0K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expanding the clinical phenotype of HIST1H1E syndrome: cerebellar atrophy and bilateral optic neuropathy, a case report.

Frontiers in neurology·2026
Same author

Impact of COVID-19 on Abdominal Pain Presentations and Hospital Outcomes in New South Wales: Findings From the ICON Study.

Emergency medicine Australasia : EMA·2025
Same author

Early Alzheimer's disease (mild cognitive impairment or mild dementia): Prevalence, diagnostics, treatment options, and guidelines in Asia, Australasia, and Pacific nations countries.

The journal of prevention of Alzheimer's disease·2025
Same author

Probability and Neurodegeneration: Alzheimer's Disease and Huntington's Disease.

Brain sciences·2025
Same author

Medicinal cannabis in neurodegenerative disorders: an open label, dose finding, safety and efficacy study.

Neurodegenerative disease management·2024
Same author

Young drivers' early access to their own car and crash risk into early adulthood: Findings from the DRIVE study.

Accident; analysis and prevention·2024

Related Experiment Video

Updated: Apr 15, 2026

Transcranial Direct Current Stimulation tDCS for Memory Enhancement
10:37

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Published on: September 18, 2021

16.3K

Statins and memory loss: An Australian experience.

Anna I Jamolowicz1, Huei-Yang Chen1, Peter K Panegyres1

  • 1Neurodegenerative Disorders Research Pty Ltd, West Perth, WA, Australia.

The Australasian Medical Journal
|April 15, 2015
PubMed
Summary

Statins, commonly used for high cholesterol, were found to have no significant difference in memory-related side effects compared to other cholesterol-lowering drugs. This analysis of Australian data suggests memory loss is not a unique adverse event of statin therapy.

Keywords:
Statinsdementiamemory loss

More Related Videos

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.2K
LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

14.3K

Related Experiment Videos

Last Updated: Apr 15, 2026

Transcranial Direct Current Stimulation tDCS for Memory Enhancement
10:37

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Published on: September 18, 2021

16.3K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.2K
LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

14.3K

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Public Health

Background:

  • Statins are primary treatments for hypercholesterolemia.
  • Public and media interest in statin side effects, including memory loss, has increased.
  • Understanding the link between statins and memory is crucial for patient safety.

Purpose of the Study:

  • To investigate the association between statin use and memory-related adverse events.
  • To compare statin-induced memory issues with those from alternative cholesterol-lowering drugs.
  • To analyze Australian data on adverse events related to cholesterol management.

Main Methods:

  • Data on total adverse events (TAE) and single suspected medicine (SSM) events for memory loss were extracted from Australian Medicare and Pharmaceutical Benefits Scheme (PBS) databases.
  • Statin and non-statin cholesterol-lowering drug data were analyzed for memory-related adverse events from January 1992 to May 2013.
  • Incidence rates of adverse events were compared between statins and non-statins, adjusting for prescription numbers.

Main Results:

  • Amnesia was the most reported memory-related event, with significantly more events linked to statins (167) than non-statins (6).
  • Total adverse events (TAE) and single suspected medicine (SSM) incidence rates for memory issues were higher for statins than non-statins.
  • However, statistical analysis revealed no significant difference in the incidence rates of memory-related adverse events between statins and non-statin cholesterol-lowering drugs (p > 0.05).

Conclusions:

  • The study found no statistically significant difference in memory-related adverse events between statins and other cholesterol-lowering medications.
  • Analysis of Australian Pharmaceutical Benefits Scheme (PBS) and Therapeutic Goods Administration (TGA) data supports this conclusion.
  • These findings may help inform public and clinical understanding of statin safety regarding cognitive function.