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Updated: Apr 15, 2026

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The association constant of 5',8-cyclo-2'-deoxyguanosine with cytidine
Amedeo Capobianco1, Tonino Caruso1, Sandra Fusco1
1Dipartimento di Chimica e Biologia, Università di Salerno Fisciano, Salerno, Italy.
Abstract:
The association of 5',8-cyclo-2'-deoxyguanosine (cdG), a DNA tandem lesion, with its complementary base cytosine has been studied by voltammetry and NMR in chloroform, using properly silylated derivatives of the two nucleobases for increasing their solubilities. Both voltammetric data and NMR titrations indicated that the Watson-Crick complex of cytidine with cdG is weaker than that with guanosine, the difference being approximately of one order of magnitude between the two association constants.
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