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Related Experiment Videos

Iron absorption from infant foods.

S J Fomon1, E E Ziegler, R R Rogers

  • 1Department of Pediatrics, College of Medicine, University of Iowa, Iowa City 52242.

Pediatric Research
|September 1, 1989
PubMed
Summary

Iron bioavailability in infant foods was assessed using stable isotope 58Fe. Fortified foods showed iron incorporation into red blood cells, indicating nutritional importance for infants.

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Area of Science:

  • Nutritional Science
  • Pediatric Nutrition
  • Biochemistry

Background:

  • Iron deficiency is a significant global health concern in infants.
  • Iron fortification of infant foods is a common strategy to prevent deficiency.
  • Assessing the bioavailability of iron from fortified foods is crucial for ensuring adequate intake.

Purpose of the Study:

  • To determine the bioavailability of iron from various iron-fortified infant foods.
  • To compare iron bioavailability from foods fortified with ferrous sulfate versus ferrous fumarate.
  • To evaluate the nutritional significance of iron absorption from fortified infant foods.

Main Methods:

  • Extrinsically labeling infant foods with stable iron isotope 58Fe.
  • Administering labeled test meals to infants at a standardized age (154 days).

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  • Measuring erythrocyte incorporation of 58Fe using mass spectrometry at follow-up blood draws.

    • Main Results:

    • Erythrocyte incorporation of iron varied across different fortified foods.
    • Mead Johnson Enriched Baby Food (MJEBF) fortified with ferrous sulfate showed lower incorporation (0.05 mg) compared to other products.
    • Vegetable-beef product showed moderate incorporation (0.08 mg), potentially affected by absorption inhibitors.
    • Cereal-fruit product, grape juice, and MJEBF fortified with ferrous fumarate showed higher incorporation (0.14-0.18 mg).

    Conclusions:

    • Iron bioavailability from fortified infant foods is variable.
    • The form of iron fortification (ferrous sulfate vs. ferrous fumarate) and food matrix may influence absorption.
    • The observed iron incorporation represents a significant contribution (20-26%) towards estimated infant iron requirements.