Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Colors and Magnetism03:02

Colors and Magnetism

14.8K
Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
14.8K
Valence Bond Theory02:42

Valence Bond Theory

11.9K
Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
11.9K
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

25.8K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
25.8K
Coordination Number and Geometry02:57

Coordination Number and Geometry

20.1K
For transition metal complexes, the coordination number determines the geometry around the central metal ion. Table 1 compares coordination numbers to molecular geometry. The most common structures of the complexes in coordination compounds are octahedral, tetrahedral, and square planar.
20.1K
Structural Isomerism02:34

Structural Isomerism

22.6K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly,...
22.6K
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

1.6K
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rhenium-186-labeled <i>ortho</i>-hydroxythiobenzhydrazide: a potential theranostic agent for use in metastatic breast cancer.

RSC advances·2026
Same author

Metal-π Interactions Between M(CO)<sub>3</sub> and Halobenzene. Cooperative Effects on Halogen Bonding.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Sulfonium cation [SF<sub>3</sub>]<sup>+</sup> complexes with noble gases.

Physical chemistry chemical physics : PCCP·2026
Same author

Human oncogenic herpesvirus latency proteins activate NEK2 to promote chromosomal instability and tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Protocol to investigate replication kinetics of Kaposi's sarcoma-associated herpesvirus using single-molecule analysis of replicated DNA.

STAR protocols·2025
Same author

Dual Noncovalent Bonding to Planar Tetracoordinated Oxygen.

The journal of physical chemistry. A·2025

Related Experiment Video

Updated: Apr 15, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

59.2K

Doubly chloro bridged dimeric copper(II) complex: magneto-structural correlation and anticancer activity.

Yeasin Sikdar1, Ritwik Modak, Dipayan Bose

  • 1Department of Chemistry, University of Calcutta, 92, A.P.C. Road, Kolkata, India. sgchem@caluniv.ac.in.

Dalton Transactions (Cambridge, England : 2003)
|April 15, 2015
PubMed
Summary

Researchers synthesized a novel copper(II) complex with a Schiff base ligand, revealing weak antiferromagnetic interactions and potential anticancer activity against HepG2 liver cancer cells.

More Related Videos

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

10.2K
Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

10.0K

Related Experiment Videos

Last Updated: Apr 15, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

59.2K
Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

10.2K
Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

10.0K

Area of Science:

  • Coordination Chemistry
  • Inorganic Chemistry
  • Materials Science

Background:

  • Schiff base ligands are versatile in coordinating with metal ions.
  • Dimeric copper(II) complexes with chloro bridges are of interest for their magnetic properties and potential applications.
  • Understanding structure-property relationships in metal complexes is crucial for developing new functional materials.

Purpose of the Study:

  • To synthesize and structurally characterize a new doubly chloro bridged dimeric copper(II) complex.
  • To investigate the magnetic properties and exchange interactions within the complex.
  • To evaluate the potential anticancer activity of the synthesized complex against liver cancer cell lines.

Main Methods:

  • Synthesis of the copper(II) complex [Cu2(μ-Cl)2(HL)2Cl2] (1) using a Schiff base ligand.
  • Single crystal X-ray diffraction for structural elucidation.
  • Magnetic studies (susceptibility measurements) and DFT calculations for magnetic interaction analysis.
  • In vitro cytotoxicity assays on liver cancer cell lines (HepG2).

Main Results:

  • The complex features dinuclear copper(II) centers with square pyramidal geometry, linked by a double chloro bridge.
  • Weak antiferromagnetic interactions (J = -0.47 cm(-1)) were observed and supported by magneto-structural correlation.
  • DFT calculations corroborated the experimental magnetic exchange value.
  • Spin density plots indicated charge distribution on copper and chlorine atoms.
  • The complex demonstrated significant cytotoxicity against HepG2 cells, involving phosphatidyl serine exposure, ROS generation, and mitochondrial depolarization.

Conclusions:

  • A novel doubly chloro bridged dimeric copper(II) complex was successfully synthesized and characterized.
  • The complex exhibits weak antiferromagnetic coupling, consistent with theoretical predictions.
  • The compound shows promising anticancer potential, particularly against the HepG2 liver cancer cell line, warranting further investigation.