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[Thrombocytic and erythrocytic components of hemostasis in bronchial asthma]
Pediatriia
|January 1, 1989
Insights
This study found that platelet aggregation is a sensitive indicator of atopic bronchial asthma severity in children. Abnormalities in microcirculatory hemostasis correlate with disease phase and intensity.
Area of Science:
- Pediatric Pulmonology
- Hemostasis Research
- Clinical Immunology
Context:
- Atopic bronchial asthma in children affects microcirculatory hemostasis.
- Hemostatic parameters deviate significantly in affected children compared to healthy controls.
- Abnormalities are most pronounced during acute asthma exacerbations.
Purpose:
- To investigate microcirculatory hemostasis in pediatric patients with atopic bronchial asthma.
- To identify sensitive biomarkers for assessing disease severity and phase.
- To correlate hemostatic changes with clinical presentation.
Summary:
- Studies involving 44 children with atopic bronchial asthma revealed distinct alterations in microcirculatory hemostasis.
- Spontaneous platelet aggregation emerged as the most sensitive indicator of these changes.
- The severity of changes in platelet aggregation correlated significantly with the disease's gravity and current phase.
Impact:
- Identifies spontaneous platelet aggregation as a key indicator for monitoring asthma in children.
- Provides insights into the pathophysiology of hemostatic disturbances in pediatric asthma.
- Suggests potential for improved clinical assessment and management strategies based on hemostatic profiles.
Abstract:
Studies of the microcirculatory component of hemostasis in 44 children suffering from atopic bronchial asthma disclosed noticeable deviations of the parameters under study from the analogous ones in normal children. The most pronounced abnormalities were recorded in the paroxysmal period of the illness. Spontaneous aggregation of platelets should be regarded as the most sensitive test. Significant changes in the test were in agreement with the disease gravity and phase.