Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ABR, an active BCR-related gene.

N Heisterkamp1, C Morris, J Groffen

  • 1Section of Molecular Diagnosis, Childrens Hospital, Los Angeles, CA 90027.

Nucleic Acids Research
|November 11, 1989
PubMed
Summary

Researchers discovered a new gene, ABR, related to the BCR gene involved in leukemia. This functionally active gene, located on chromosome 17p, shows significant genomic variability unlike the BCR gene on chromosome 22.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving on-call efficiency: impact of the orthopaedic grab-bag in major trauma centres and trauma units.

Annals of the Royal College of Surgeons of England·2026
Same author

How can we use distance education to teach medicine in conflict-affected countries?

Medicine, conflict, and survival·2024
Same author

The World Rugby and International Rugby Players Contact Load Guidelines: From conception to implementation and the future.

South African journal of sports medicine·2024
Same author

Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC.

The European physical journal. C, Particles and fields·2022
Same author

Effect of different durations of using a standing frame on the rate of hip migration in children with moderate to severe cerebral palsy: a feasibility study for a randomised controlled trial.

Physiotherapy·2022
Same author

Prospects for beyond the Standard Model physics searches at the Deep Underground Neutrino Experiment: DUNE Collaboration.

The European physical journal. C, Particles and fields·2021

Area of Science:

  • Genetics
  • Molecular Biology
  • Cancer Research

Background:

  • The BCR gene on chromosome 22 is implicated in the Philadelphia translocation (t(9;22)), a key genetic abnormality in chronic myeloid leukemia and acute lymphoblastic leukemia.
  • Breakpoint regions within the BCR gene, specifically the major breakpoint cluster region (Mbcr), are frequently involved in this translocation.
  • Previous studies indicated the presence of BCR gene-related sequences in the human genome.

Purpose of the Study:

  • To identify and characterize novel BCR gene-related sequences.
  • To investigate the functional activity and genomic location of a newly discovered BCR-related locus.
  • To compare the structural and genomic features of the novel gene with the known BCR gene.

Main Methods:

  • Molecular cloning techniques were employed to isolate BCR gene-related sequences.
  • Hybridization experiments were used to detect and map gene loci.
  • Sequence analysis was performed to compare exon similarity and identify genomic variability.

Main Results:

  • A novel BCR gene-related locus, named ABR, was molecularly cloned.
  • The ABR gene was found to be functionally active and possesses exons similar to the BCR gene's Mbcr.
  • Unlike the BCR gene (chromosome 22), the ABR gene is located on chromosome 17p and displays significant genomic variability due to tandem repeat regions in its introns.

Conclusions:

  • The discovery of the ABR gene expands the understanding of the BCR gene family.
  • The unique genomic location and variability of ABR suggest distinct biological roles compared to BCR.
  • Further research into ABR's function may offer new insights into leukemogenesis and potential therapeutic targets.

Related Experiment Videos