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Updated: Apr 15, 2026

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

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MicroRNA signatures of platinum-resistance in ovarian cancer

H C Ying, H Y Xu, J Lv

    European Journal of Gynaecological Oncology
    |April 16, 2015
    PubMed
    Abstract

    Insights

    This study identified miR-141-3p as a significantly upregulated microRNA in platinum-resistant ovarian cancer cells. It shows potential as a therapeutic target and biomarker for predicting chemotherapy response.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Genetics

    Background:

    • Ovarian cancer often develops platinum resistance, necessitating novel therapeutic strategies.
    • MicroRNAs (miRNAs) play crucial roles in cancer development and drug resistance.
    • Identifying specific miRNAs associated with platinum resistance is vital for improving treatment outcomes.

    Purpose of the Study:

    • To compare differentially expressed miRNAs in platinum-resistant ovarian cancer cells.
    • To identify potential biomarkers for predicting response to platinum-based chemotherapy.

    Main Methods:

    • Utilized miRNA array technology to analyze miRNA expression profiles.
    • Compared miRNA expression between platinum-sensitive (COC1) and platinum-resistant (COC1/DDP) ovarian cancer cell lines.
    • Validated differential expression using real-time quantitative polymerase chain reaction (qRT-PCR).

    Main Results:

    • Identified several differentially expressed miRNAs in ovarian cancer cell lines.
    • Found four significantly deregulated and 13 upregulated miRNAs.
    • miR-141-3p exhibited the most significant differential expression, being highly upregulated in platinum-resistant cells (p < 0.05).
    • qRT-PCR confirmed significantly higher miR-141-3p expression in chemotherapy-resistant versus sensitive groups (p < 0.05).

    Conclusions:

    • miR-141-3p is a promising candidate for therapeutic targeting to overcome platinum resistance.
    • miR-141-3p may serve as a valuable biomarker for predicting patient response to platinum-based chemotherapy.

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