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Updated: Apr 14, 2026

Identification of Circular RNAs using RNA Sequencing
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Identification of Circular RNAs using RNA Sequencing

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The emerging landscape of circular RNA ciRS-7 in cancer (Review)

Li Peng1, Xiao Qing Yuan2, Guan Cheng Li1

  • 1Cancer Research Institute, Central South University; Key Laboratory of Carcinogenesis, National Health and Family Planning Commission; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, P.R. China.

Oncology Reports
|April 16, 2015
PubMed

Insights

Circular RNAs (circRNAs) are novel molecules regulating gene expression. The ciRS-7 circRNA acts as a

Area of Science:

  • * Molecular Biology
  • * Genetics
  • * Oncology

Background:

  • * Circular RNAs (circRNAs) are a class of non-coding RNA molecules found in eukaryotic cells.
  • * CircRNAs originate from various RNA precursors through diverse biogenesis pathways.
  • * The specific circRNA ciRS-7 has been identified as a regulator of microRNAs (miRNAs), messenger RNAs (mRNAs), and RNA-binding proteins (RBPs).

Purpose of the Study:

  • * To review the biogenesis and functions of the circRNA ciRS-7.
  • * To explore the role of ciRS-7 as a competing endogenous RNA (ceRNA), specifically its interaction with microRNA-7 (miR-7).
  • * To discuss the implications of the ciRS-7/miR-7 interaction in the context of cancer development and progression.

Main Methods:

  • * Literature review and synthesis of existing research on circRNAs, particularly ciRS-7.
  • * Analysis of studies investigating the molecular mechanisms of ciRS-7.
  • * Examination of data linking ciRS-7 and its targets to oncogenesis.

Main Results:

  • * ciRS-7 functions as a potent 'super sponge' for miR-7, sequestering and inhibiting its activity.
  • * This competitive interaction between ciRS-7 and miR-7 influences the expression of downstream targets.
  • * Dysregulation of the ciRS-7/miR-7 axis is implicated in various cancers.

Conclusions:

  • * ciRS-7 plays a significant role in gene regulation through its interaction with miR-7.
  • * The ciRS-7/miR-7 pathway represents a potential target for cancer therapy.
  • * Further research is warranted to fully elucidate the complex roles of ciRS-7 in oncogenesis.

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