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Related Concept Videos

Dementia01:30

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Related Experiment Video

Updated: Apr 14, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
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[Updated Dementia guideline: reflections from primary care].

Marieke Perry1, Eric P Moll van Charante

  • 1Radboudumc, afd. Eerstelijnsgeneeskunde, Nijmegen.

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|April 16, 2015
PubMed
Summary

The updated Dementia guideline suggests limited diagnostic testing, contrasting with current trends. It also recommends Alzheimer's disease treatments with cholinesterase inhibitors or memantine, despite questionable clinical relevance.

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Area of Science:

  • Geriatrics
  • Neurology
  • Clinical Practice Guidelines

Background:

  • The Dutch Geriatrics Society (NVKG) updated its Dementia guideline.
  • There is a perceived trend towards comprehensive testing in memory clinics.
  • Existing guidelines offer varying recommendations on diagnostic testing and pharmacotherapy.

Purpose of the Study:

  • To analyze the recommendations of the updated NVKG Dementia guideline.
  • To compare the NVKG guideline's approach to diagnostic testing and pharmacotherapy with current practices and other benchmarks.
  • To evaluate the clinical relevance of recommended treatments and the importance of psychosocial interventions.

Main Methods:

  • Guideline analysis and comparison.
  • Review of meta-analyses on treatment efficacy.
  • Assessment of diagnostic test utility and patient burden.

Main Results:

  • The NVKG guideline advocates for additional diagnostic testing (EEG, CSF, imaging) only when significant diagnostic uncertainty persists.
  • This contrasts with a trend of using full test batteries for all patients in memory clinics.
  • The guideline recommends cholinesterase inhibitors or memantine for Alzheimer's disease, acknowledging meta-analyses but questioning clinical relevance due to short-lived effects and adverse events.
  • Significant emphasis is placed on psychosocial interventions for patient and carer quality of life.

Conclusions:

  • The NVKG Dementia guideline promotes a more parsimonious approach to diagnostic testing, potentially improving efficiency and reducing patient burden.
  • The recommendation for pharmacotherapy in Alzheimer's disease is noted, but its clinical benefit is questioned.
  • Psychosocial interventions are highlighted as crucial for enhancing the quality of life for individuals with dementia and their caregivers.