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Related Experiment Video

Updated: Apr 14, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Longitudinal changes in left ventricular diastolic function in a general population.

Tatiana Kuznetsova1, Lutgarde Thijs2, Judita Knez2

  • 1From the Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium (T.K., L.T., J.K., N.C., T.P., Y-M.G., Z.Z., J.A.S.). tatiana.kouznetsova@med.kuleuven.be.

Circulation. Cardiovascular Imaging
|April 16, 2015
PubMed
Summary
This summary is machine-generated.

Left ventricular diastolic function (LVDF) often worsens with age. Higher baseline insulin, blood pressure, and heart rate predict worsening LVDF, highlighting key factors for monitoring diastolic health.

Keywords:
Doppler echocardiographyepidemiologyleft ventricular functionlongitudinal survey

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Area of Science:

  • Cardiology
  • Diabetology
  • Gerontology

Background:

  • Longitudinal data on changes in left ventricular diastolic function (LVDF) in the general population are limited.
  • Understanding factors influencing LVDF over time is crucial for cardiovascular health assessment.

Purpose of the Study:

  • To investigate clinical correlates of longitudinal changes in Doppler diastolic indexes.
  • To identify factors predictive of changes in LVDF grades over time in a population cohort.

Main Methods:

  • Assessed mitral inflow (E, A) and mitral annular velocities (e', a') using Doppler and tissue Doppler imaging in 650 participants.
  • Analyzed Doppler diastolic indexes as continuous measures and LVDF grades over a mean follow-up of 4.7 years.
  • Utilized stepwise regression to identify multivariable-adjusted correlates and predictors of LVDF changes.

Main Results:

  • LVDF grades remained unchanged in 87.2%, improved in 3.7%, and worsened in 9.1% of participants.
  • Baseline age, higher baseline serum insulin, and baseline diastolic blood pressure were significant predictors of worsening LVDF.
  • Changes in systolic blood pressure over time also predicted worsening of LVDF.

Conclusions:

  • LVDF tends to worsen over time in the general population.
  • Advanced age, elevated baseline insulin levels, and hemodynamic parameters (heart rate, blood pressure) are associated with worsening LVDF.
  • These findings emphasize the importance of monitoring diastolic function in relation to metabolic and hemodynamic factors.