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Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
Published on: August 19, 2020
Acute Epstein-Barr virus infection-associated collapsing glomerulopathy
Amit Joshi1, Amit Arora2, David Cimbaluk3
1Division of Nephrology , John H. Stroger Hospital of Cook County , Chicago, IL , USA.
Abstract:
A 21-year-old woman presenting with acute Epstein-Barr virus (EBV) infection (infectious mononucleosis) was noted to have renal involvement. She had proteinuria, leukocyturia and microscopic hematuria, and 10 days after admission became nephrotic (23 g of protein per g of creatinine). Renal biopsy revealed glomerular tuft collapse, visceral epithelial cell proliferation and vacuolization consistent with collapsing glomerulopathy. She had only transient deterioration in renal function, attributed to contrast nephropathy, but after recovery remained proteinuric. Renal disease is well described in EBV infection, but collapsing glomerulopathy has not been reported previously.
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