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Acute Epstein-Barr virus infection-associated collapsing glomerulopathy.

Amit Joshi1, Amit Arora2, David Cimbaluk3

  • 1Division of Nephrology , John H. Stroger Hospital of Cook County , Chicago, IL , USA.

Clinical Kidney Journal
|April 16, 2015
PubMed
Summary

Epstein-Barr virus (EBV) infection, also known as infectious mononucleosis, can cause kidney damage. This case report details a patient who developed collapsing glomerulopathy, a rare kidney disease, following an EBV infection.

Keywords:
collapsing glomerulopathyinfectious mononucleosisnephrotic syndrome

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Area of Science:

  • Nephrology
  • Virology
  • Pathology

Background:

  • Epstein-Barr virus (EBV) infection, or infectious mononucleosis, is common but can lead to various complications.
  • Renal involvement in EBV infection is documented, though typically presents as acute kidney injury or glomerulonephritis.
  • Collapsing glomerulopathy is a severe form of kidney disease characterized by glomerular tuft collapse.

Purpose of the Study:

  • To report a novel association between Epstein-Barr virus infection and collapsing glomerulopathy.
  • To describe the clinical presentation, renal biopsy findings, and outcome of a patient with EBV-associated collapsing glomerulopathy.

Main Methods:

  • Case report of a 21-year-old woman with acute EBV infection.
  • Clinical assessment including urinalysis and laboratory tests for renal function.
  • Renal biopsy for histopathological examination.

Main Results:

  • The patient presented with proteinuria, leukocyturia, and microscopic hematuria, progressing to nephrotic syndrome.
  • Renal biopsy confirmed collapsing glomerulopathy with glomerular tuft collapse and visceral epithelial cell changes.
  • Renal function transiently declined but recovered, with persistent proteinuria.

Conclusions:

  • This case suggests a potential link between Epstein-Barr virus infection and the development of collapsing glomerulopathy.
  • Collapsing glomerulopathy is a previously unreported renal manifestation of EBV infection.
  • Further research is needed to elucidate the mechanisms underlying this association and its clinical significance.