Related Experiment Video
Updated: Apr 14, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Hypertension and a missing kidney
Rupesh Raina1, Vikas Gulani2, Lina Mehta2
1Division of Pediatric Nephrology, Department of Pediatrics , University Hospitals of Cleveland , Cleveland OH , USA.
Abstract:
Standard initial assessment via ultrasound of a 4-year-old girl with hypertension revealed the absence of one kidney. Instead of cross-sectional imaging of the retroperitoneal space, a functional (nuclear) study was performed. This revealed a malformed kidney within the chest. Though systemic levels of renin and aldosterone were not elevated, removal of the malformed kidney normalized the blood pressure. The presence of prominent smooth muscle nodules surrounding the arteries was seen in the malformed kidney. Initial attempts to avert surgery by pharmacologically reducing blood flow to the malformed kidney were unsuccessful. The review of the literature offers little evidence to support such a strategy.
More Related Videos
Related Concept Videos
Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension and Regulation of Blood Pressure
Antihypertensive Drugs: Potassium-Sparing Diuretics
Hypertension II: Pathophysiology
Chronic Kidney Disease I: Introduction
Hypertension I: Introduction

