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Daptomycin for a complicated urinary tract infection with vancomycin-resistant Enterococcus faecium in a renal

Gabriele Eden1, Olaf Burkhardt2, Christian Clajus1

  • 1Department of Nephrology and Hypertension , Medical School Hannover , Hannover , Germany.

Clinical Kidney Journal
|April 16, 2015
PubMed

Insights

This case study highlights daptomycin as a potential treatment for urinary tract infections (UTIs) caused by vancomycin-resistant Enterococcus faecium. Early administration of daptomycin led to rapid clinical improvement and graft function recovery.

Area of Science:

  • Infectious Diseases
  • Nephrology
  • Pharmacology

Background:

  • Increasing prevalence of multidrug-resistant Gram-negative bacilli and Gram-positive enterococci causing urinary tract infections (UTIs).
  • High rates (up to 25%) of vancomycin resistance in enterococci pose significant treatment challenges.

Purpose of the Study:

  • To report a case of UTI caused by vancomycin-resistant Enterococcus faecium (VRE).
  • To evaluate the efficacy of daptomycin in treating VRE-UTI.

Main Methods:

  • A 68-year-old female patient with VRE-UTI was treated with daptomycin.
  • Clinical and laboratory parameters were monitored following daptomycin administration.

Main Results:

  • The patient's UTI was caused by vancomycin-resistant Enterococcus faecium, susceptible only to gentamycin, linezolid, and daptomycin.
  • Within 24 hours of daptomycin treatment, clinical and laboratory signs of infection significantly regressed.
  • Graft function also recovered following daptomycin therapy.

Conclusions:

  • Daptomycin demonstrated rapid clinical and laboratory efficacy in this VRE-UTI case.
  • Daptomycin may represent an effective therapeutic alternative for UTIs caused by vancomycin-resistant enterococci.
Keywords:
renal transplant recipienturinary tract infectionvancomycin-resistant entorococci

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