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Potential antihypertensive benzimidazole derivatives
B Serafin1, G Borkowska, J Główczyk
1Institute of Organic Technology, Technical University (Politechnika), Warszaw, Poland.
Polish Journal of Pharmacology and Pharmacy
|January 1, 1989
Abstract:
A series of benzimidazole derivatives was synthesized and tested for their hypotensive activity. The most interesting compounds were: BS1/81 (2-guanidino-benzimidazole) and BS1/84 (2-guanidino-5-aminobenzimidazole dihydrochloride), which effects were comparable to those of aminophylline. It was found that substitution of guanidine nitrogen atom with phenyl group caused a distinct decrease of activity while cyclization of guanidine rest to pyrimidine ring caused only a small decrease of activity.