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Occult hepatitis B infection in children with chronic liver disease

Anshu Srivastava1, Amrita Mathias, Surender K Yachha

  • 1Departments of aPediatric Gastroenterology bGastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

European Journal of Gastroenterology & Hepatology
|April 16, 2015
PubMed

Insights

Occult hepatitis B infection (OBI) is infrequent in Indian children with chronic liver disease (CLD). This study found OBI prevalence similar in cryptogenic and known-etiology CLD, suggesting it may not significantly impact outcomes in this pediatric population.

Area of Science:

  • Hepatology
  • Pediatric Gastroenterology
  • Infectious Diseases

Background:

  • Occult hepatitis B infection (OBI) can worsen outcomes in chronic liver disease (CLD).
  • Data on OBI in pediatric CLD is lacking.
  • This study addresses the prevalence and impact of OBI in HBsAg-negative children with CLD.

Purpose of the Study:

  • To determine the prevalence of OBI in HBsAg-negative children with CLD.
  • To assess the effect of OBI on disease severity in this population.
  • To compare OBI prevalence between cryptogenic CLD and CLD of known etiology.

Main Methods:

  • Prospective evaluation of 115 HBsAg-negative CLD children.
  • Testing for hepatitis B exposure (total anti-HBc, anti-HBs).
  • Hepatitis B virus DNA measurement in anti-HBc positive cases.

Main Results:

  • 39.1% of children showed evidence of HBV exposure.
  • 4 out of 45 exposed children had seropositive OBI.
  • Anti-HBc positive children had higher Child's scores, indicating more severe CLD.
  • OBI prevalence was similar in cryptogenic and known-etiology CLD.

Conclusions:

  • Seropositive OBI is infrequent in Indian children with CLD.
  • The prevalence of OBI is comparable in cryptogenic and known-etiology CLD.
  • OBI may not be a significant factor in disease severity in this pediatric group.
Abstract

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