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Simvastatin improves incisional wound healing in a rat model: an experimental study
Hayrullah Derici1, Ismail Yaman2, Cemal Kara3
1Department of General Surgery, Balikesir Medical University, Balikesir, Turkey;
Unlabelled:
This study investigated the effect of simvastatin on the heal- ing process of abdominal wall wounds in rats.
Methods:
The study was performed with adult female Wistar-Albino rats. Control group (n = 20) rats were fed standard laboratory diet until 12 hours before sur- gery. Study group (n = 20) rats received oral simvastatin therapy with an orogastric tube (10 mg/kg once a day) for 7 days until 12 hours before surgery. Each rat was anesthetized, and a 4 cm-long midline laparotomy was performed. Ten animals from each group were killed at postoperative days (PODs) 7 and 14. Breaking strength analysis was measured, and the abdominal incision wounds were examined histolog- ically.
Results:
Hydroxyproline levels and tensile strength of abdominal fascia were significantly higher in the study group on PODs 7 and 14 compared to the control group. The granulation tissue fibroblast matu- ration scores on POD 7, and both collagen deposition scores and neo- vascularization scores on PODs 7 and 14, were found to be statistically significantly higher in the simvastatin treatment group compared to the control group, based on the results of the histologic tissue examina- tions.
Conclusion:
Simvastatin can be used as a supporting therapy in wound healing. .
