Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Oral Microbiota01:27

The Oral Microbiota

57
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
57
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

42
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
42
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

41
The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
41
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

60
Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
60
Colonisation of Pathogens01:25

Colonisation of Pathogens

59
Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
59
Introduction to Epidemiology01:26

Introduction to Epidemiology

2.6K
Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and radiographic outcomes following open Latarjet with single button technique.

JSES reviews, reports, and techniques·2026
Same author

Risk Factors and Management of Gingival Enlargement: A Systematic Review and Meta-Analysis.

Journal of clinical periodontology·2026
Same author

Systemic Antibiotics in the Surgical Treatment of Peri-Implantitis: Impact on the Salivary Microbiome.

Journal of clinical periodontology·2026
Same author

Gingival and Periodontal Diseases and Conditions in Children and Adolescents: Consensus Report.

Journal of clinical periodontology·2026
Same author

Gingival and periodontal diseases and conditions in children and adolescents: consensus report.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2026
Same author

<i>Filifactor alocis</i> FtxA blocks inflammation and apoptosis pathways in monocytic cells.

Frontiers in cellular and infection microbiology·2026

Related Experiment Video

Updated: Apr 14, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

12.6K

On putative periodontal pathogens: an epidemiological perspective.

Rodrigo Lopez1, Philippe Hujoel, Georgios N Belibasakis

  • 1a Section of Periodontology; Faculty of Health Sciences; Aarhus University ; Aarhus , Denmark.

Virulence
|April 16, 2015
PubMed
Summary

This review examines the microbiology of periodontitis, finding limited evidence and methodological challenges in identifying specific bacterial causes. Further research is needed to establish definitive causal links for this common gum disease.

Keywords:
causalitycohort studiesepidemiologygerm theory of diseaseinfectionperiodontitis

More Related Videos

Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells
12:16

Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells

Published on: December 17, 2015

27.2K
In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA
11:15

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

Published on: May 21, 2015

11.5K

Related Experiment Videos

Last Updated: Apr 14, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

12.6K
Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells
12:16

Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells

Published on: December 17, 2015

27.2K
In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA
11:15

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

Published on: May 21, 2015

11.5K

Area of Science:

  • Periodontology
  • Oral Microbiology
  • Epidemiology

Background:

  • Periodontitis is a complex oral disease with multifactorial etiology.
  • The role of specific microbial agents in periodontitis causation remains debated.
  • Current understanding relies on a combination of clinical, microbiological, and immunological data.

Purpose of the Study:

  • To critically review the current understanding of the role of microbiology in periodontitis causation.
  • To identify limitations and challenges in investigating candidate periodontal pathogens.
  • To discuss aspects of causal inference in the context of periodontitis.

Main Methods:

  • Comprehensive literature appraisal focusing on microbiological and epidemiological studies.
  • Analysis of existing evidence regarding periodontal pathogens.
  • Discussion of established criteria for causal inference.

Main Results:

  • Significant challenges exist in isolating and investigating specific periodontal pathogens.
  • Limited epidemiological evidence currently supports a direct causal role for individual microbial species.
  • Methodological issues have hindered definitive etiological investigations.

Conclusions:

  • The etiological role of specific microorganisms in periodontitis requires further rigorous investigation.
  • Enhanced epidemiological studies and improved causal inference models are necessary.
  • A clearer understanding of microbial contributions is crucial for effective periodontitis prevention and treatment.