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Updated: Apr 14, 2026

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

Colorimetric logic response based on aptamer functionalized colloidal crystal hydrogels.

Baofen Ye¹, Huan Wang, Haibo Ding

¹State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, China. gu@seu.edu.cn yjzhao@seu.edu.cn.

|April 16, 2015

Summary

This summary is machine-generated.

A new colorimetric logic system using aptamer-cross-linked colloidal crystal hydrogels (CCH) was created. This system visually represents logic gates like "OR" and "AND" in response to mercury and silver ions.

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Area of Science:

Biomaterials Science
Nanotechnology
Chemical Sensing

Background:

Colloidal crystal hydrogels (CCH) offer tunable optical properties.
Aptamers provide specific molecular recognition capabilities.
Developing integrated logic systems for environmental monitoring is crucial.

Purpose of the Study:

To develop a novel colorimetric logic system.
To utilize aptamer-functionalized CCH for ion detection.
To achieve visual output for logic operations.

Main Methods:

Fabrication of aptamer-cross-linked colloidal crystal hydrogels.
Exposure of the CCH to target ions (Hg(2+) and Ag(+)).
Observation of hydrogel response (shrinking) and color change.

Main Results:

The CCH exhibited a shrinking response to Hg(2+) and Ag(+).
Color changes corresponded to logical "OR" and "AND" gate operations.
Visual output signals for the logic gates were successfully realized.

Conclusions:

Aptamer-CCH is a viable platform for colorimetric logic systems.
The system demonstrates potential for visual detection of specific metal ions.
This approach offers a new strategy for developing smart sensors.