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Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood
Published on: April 16, 2016
A double-enhanced strip biosensor for the rapid and ultrasensitive detection of protein biomarkers
Chunyan Qin1, Wei Wen, Xiuhua Zhang
1Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules & College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, P. R. China. wangsf@hubu.edu.cn.
Abstract:
Combining the specific molecular recognition reaction between biotin and streptavidin with a dual-class signal amplification system, containing the unique optical properties of gold nanoparticles and the catalytic reaction of horseradish peroxidase, a double-enhanced strip biosensor was designed for the first time for a visual and rapid detection of protein biomarkers with good accuracy, especially for CEA with a detection limit of 2.9 fg mL(-1).
