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Panic disorder and incident coronary heart disease: a systematic review and meta-analysis protocol

Phillip J Tully1,2, Gary A Wittert3, Deborah A Turnbull4

  • 1Department of Rehabilitation Psychology and Psychotherapy, Institute of Psychology, University of Freiburg, Engelbergerstr. 41, Freiburg, 79085, Germany. phillip.tully@adelaide.edu.au.

Systematic Reviews
|April 16, 2015
PubMed

Insights

This systematic review investigates the link between panic disorder and subsequent coronary heart disease (CHD). Findings may inform clinical practice for chest pain patients and those with panic disorder.

Area of Science:

  • Cardiology
  • Psychiatry
  • Epidemiology

Background:

  • Panic disorder and coronary heart disease (CHD) share overlapping clinical symptoms.
  • The etiological relationship between panic disorder and CHD is controversial and not well-established.
  • This systematic review aims to synthesize existing data on panic disorder and incident CHD or myocardial infarction.

Purpose of the Study:

  • To clarify the association between panic disorder and an elevated risk of subsequent CHD.
  • To evaluate the etiological links between panic disorder and incident CHD.
  • To inform clinical practice and policy regarding chest pain assessment and management of panic disorder patients.

Main Methods:

  • Systematic review of electronic databases (MEDLINE, EMBASE, PsycINFO, SCOPUS).
  • Inclusion of studies on individuals without CHD who meet criteria for panic disorder or related conditions.
  • Meta-analytic methods will synthesize data on CHD outcomes, including fatal and non-fatal events.

Main Results:

  • Data extraction will focus on verified fatal and non-fatal CHD, excluding self-reported outcomes.
  • Hazard ratios and risk ratios will be extracted for meta-analysis.
  • Risk of bias assessment and data extraction will be performed by two independent reviewers.

Conclusions:

  • This review seeks to determine if panic disorder increases the risk of developing CHD.
  • Understanding this association can improve diagnostic and treatment strategies for patients presenting with chest pain and panic disorder.
  • Evidence-based recommendations for clinical practice and policy may be developed.
Abstract

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