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Health state utility values for diabetic retinopathy: protocol for a systematic review and meta-analysis
Christopher J Sampson1, Jonathan C Tosh2, Christopher P Cheyne3
1Division of Rehabilitation and Ageing, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, UK. chris.sampson@nottingham.ac.uk.
Systematic Reviews
|April 16, 2015
Summary
Diabetic retinopathy significantly lowers quality of life. This systematic review synthesizes health state utility values (HSUVs) for diabetic retinopathy stages, crucial for economic evaluations and reducing bias in healthcare technology assessments.
Area of Science:
- Ophthalmology
- Health Economics
- Evidence Synthesis
Background:
- Diabetic retinopathy (DR) is associated with reduced health-related quality of life (HRQoL).
- Screening and treatment strategies for DR are cost-effective.
- Health state utility values (HSUVs) are essential for accurate economic evaluations and decision modeling in healthcare.
Purpose of the Study:
- To systematically review and synthesize available HSUVs for individuals with diabetic retinopathy.
- To correlate HSUVs with disease progression stages and visual acuity.
- To provide a foundation for unbiased cost-effectiveness analyses of DR interventions.
Main Methods:
- Systematic literature search across multiple databases (Medline, EMBASE, Web of Science, etc.).
- Inclusion of English-language articles reporting HSUVs for DR.
- Data synthesis using linear mixed-effects modeling meta-regression.
- Mapping of reported disease severity to a standardized four-level DR grading scale.
Main Results:
- This section is to be filled after the study is conducted and data is analyzed.
Conclusions:
- The systematic review and meta-analysis will yield critical evidence for economic evaluations of DR technologies.
- Meta-regression will allow estimation of utility values across different disease stages and patient characteristics.
- This study will identify influences of study design and HSUV instruments on reported values.
