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Cutaneous myofibroma.

K J Smith1, H G Skelton, T L Barrett

  • 1Department of Dermatopathology, Armed Forces Institute of Pathology, Washington, D.C.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|November 1, 1989
PubMed
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This study describes an acquired skin tumor, similar to infantile myofibromatosis, found in adults. The benign neoplasm is of probable vascular origin and does not recur or metastasize after surgical removal.

Area of Science:

  • Dermatopathology
  • Surgical Pathology
  • Neoplastic Pathology

Background:

  • Infantile myofibromatosis is a known condition typically affecting newborns and infants.
  • Acquired skin tumors can present with diverse histological features.
  • Distinguishing benign from malignant neoplastic lesions is crucial for patient management.

Purpose of the Study:

  • To present the clinical and pathological features of an acquired skin tumor.
  • To compare this entity with infantile myofibromatosis.
  • To determine the behavior and origin of this acquired neoplasm.

Main Methods:

  • Retrospective review of 34 cases of acquired skin tumors.
  • Histopathological and ultrastructural examination of tumor samples.

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  • Immunohistochemical analysis for muscle actin expression.

    • Main Results:

    • The acquired tumor histologically resembles infantile myofibromatosis but occurs in older patients (median age 36).
    • Lesions were well-circumscribed with a biphasic pattern, showing vascular tumor features.
    • Ultrastructural and immunohistochemical findings suggest myofibroblastic and vascular origins; no recurrence or metastasis was observed.

    Conclusions:

    • This acquired skin and soft tissue neoplasm is a distinct benign entity.
    • It shares histological similarities with infantile myofibromatosis but is not limited to children.
    • The tumor is likely of vascular origin and has a favorable prognosis with surgical excision.