Comparison of Matrix with Humphrey Field Analyzer II with SITA

Area of Science:

• Ophthalmology
• Visual Psychophysics
• Medical Device Technology

Background:

• Glaucoma diagnosis and monitoring rely on accurate visual field testing.
• Contrast sensitivity measurement is crucial for detecting early glaucomatous changes.
• Comparing new perimetry technologies with established standards is essential for clinical adoption.

Purpose of the Study:

• To compare the performance of the Matrix perimeter with the Humphrey Field Analyzer II (HFA).
• To evaluate contrast sensitivity measurements across different disease severities.
• To assess the repeatability and agreement between the two perimetry devices.

Main Methods:

• Fifty-three subjects (50 glaucoma, 3 normal) underwent visual field testing on both perimeters over five sessions.
• Intraclass correlation coefficients (ICC) for mean deviation (MD) and pattern standard deviation (PSD) were calculated.
• Repeatability of sensitivity estimates and agreement between instruments were analyzed using principal curve analysis.

Main Results:

• Both perimeters demonstrated high ICC (>0.90) for MD and PSD.
• A 1 dB difference on Matrix corresponded to a 2 dB difference on HFA for sensitivities above 20 dB.
• Matrix showed less dependence of measurement variability on disease severity compared to HFA, though high variability occurred at specific dB levels.

Conclusions:

• Decibel values from Matrix and HFA are not directly interchangeable.
• Matrix may offer more stable results across varying disease severities than HFA.
• Duplicate testing is recommended for Matrix, particularly for baseline and follow-up assessments in glaucoma management.