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What Is a Clinically Relevant Improvement in Quality of Life in Adults With ADHD?
Yoko Tanaka1, Meryl Brod2, Jeannine R Lane3
11 Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.
Objective:
To estimate a minimal clinically important difference (MCID) on the adult ADHD Quality of Life (AAQoL) scale.
Method:
The MCID was determined from data from short-term ( N = 537) and long-term ( N = 440), placebo-controlled atomoxetine trials in adults with ADHD. For the anchor-based approach, change in clinician-rated Clinical Global Impressions-ADHD-Severity (CGI-ADHD-S) scores was used to derive MCID. For the distribution-based approach, baseline-to-endpoint mean ( SD) changes in AAQoL scores corresponding to 0.5 SD were computed.
Results:
The MCID was similar (approximately 8-point difference) between the short-term and the long-term treatment groups when either the anchor-based or distribution-based approach was used.
Conclusion:
These results suggest that approximately 8 points in the change from baseline on the AAQoL is a MCID.
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