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Particle engineering in pharmaceutical solids processing: surface energy considerations.

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  • 1Department of Chemical Engineering, Imperial College London, Prince Consort Road, Kensington London SW7 2AZ, United Kingdom. d.r.williams@imperial.ac.uk.

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Summary
This summary is machine-generated.

Surface energy is crucial for pharmaceutical particle engineering, impacting processes like milling and granulation. Understanding surface energy improves drug product performance and manufacturing efficiency.

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Area of Science:

  • Pharmaceutical Science
  • Materials Science
  • Chemical Engineering

Background:

  • Particle engineering is vital in pharmaceutical manufacturing.
  • Key operations include milling, granulation, crystallization, and powder mixing.
  • Surface energy significantly influences these processes and final product performance.

Purpose of the Study:

  • To review the role of surface energy in pharmaceutical particle processing.
  • To discuss methods for measuring surface energy.
  • To explore the impact of surface energy on various manufacturing operations and drug delivery systems.

Main Methods:

  • Literature review focusing on surface energy in pharmaceutical particle engineering.
  • Analysis of studies on surface energy measurement techniques.
  • Examination of research linking surface energy to milling, granulation, powder mixing, and dry powder inhaler (DPI) performance.

Main Results:

  • Surface energy and its heterogeneity are key factors in crystalline solids processing.
  • Milling significantly affects powder surface energy.
  • Surface energy influences adhesion, cohesion, granulation, and DPI system performance.

Conclusions:

  • The importance of surface energy in pharmaceutical particulate processes and products is well-established.
  • Further research is needed to refine measurement methods and define the limits of surface energy's relevance.