[Principles of the organization of intestinal epithelium and its recovery from damage revealed by modeling]

Using the developed method of modelling the curves of the fraction of labelled indexes (FLI) in the small intestine epithelium, a relationship was found between the FLI shape and duration of the S phase and the whole generation cycle for various generations of proliferating crypt cells. On the basis of the comparison between the theoretical and experimental FLI the normal values of the generation cycles along the crypt were specified for various intestinal parts. FLI were shaped along the crypt at various time intervals after irradiation. As a result, the data were obtained on the correlation between the duration of generation cycles and their phases during the postirradiation period and for various cell generations.