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An Implantable Drug-delivery System on a Chip
Meng-Shiue Lee, Da-Jeng Yao, Wensyang Hsu1
1Department of Mechanical Engineering, National Chiao Tung University, Taiwan. whsu@mail.nctu.edu.tw.
Current Topics in Medicinal Chemistry
|April 17, 2015
Summary
Implantable drug delivery systems, using microfluidic chips, offer flexible dosing like zero order or on-demand release. This review compares active and passive systems, focusing on performance and applications.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Drug Delivery Systems
Background:
- Implantable drug delivery systems represent an advanced strategy in pharmaceutical therapy.
- These systems often utilize microfluidic chips fabricated with micro/nanotechnology for precise drug administration.
Purpose of the Study:
- To review current research on implantable drug delivery systems.
- To focus on chip performance, applications, and compare active versus passive systems.
Main Methods:
- Review of existing literature on implantable drug delivery technologies.
- Analysis of microfluidic chip fabrication methods and dimensional constraints.
- Evaluation of different drug release profiles (zero order, pulsatile, on-demand).
Main Results:
- Implantable systems offer diverse drug release profiles beyond sustained release.
- Systems are classified as active (controllable) or passive (uncontrollable) based on release mechanisms.
- Performance and applications vary significantly between active and passive systems.
Conclusions:
- Implantable drug delivery systems provide enhanced therapeutic flexibility.
- Understanding the nuances of active and passive systems is crucial for optimizing drug therapy.
- Future research should continue to explore chip performance and novel applications.
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