[Is there a healthy obese subtype in cohort undergoing test for endothelial dysfunction?]

Area of Science:

• Cardiovascular Health
• Metabolic Health
• Endocrinology

Background:

• Obesity is a growing global health concern.
• The existence of a
• healthy obese
• subtype remains debated.
• Endothelial dysfunction is an early marker of cardiovascular disease.

Purpose of the Study:

• To determine if a metabolically healthy obese subtype exists.
• To investigate endothelial function in obese individuals with and without metabolic abnormalities.
• To identify factors contributing to endothelial dysfunction in obesity.

Main Methods:

• Recruited 116 healthy subjects, categorized into normal weight/metabolic normality (NMN), obesity/metabolic normality (OMN), and obesity/metabolic abnormality (OMA) groups.
• Measured anthropometric parameters, blood glucose, lipids, insulin, high-sensitivity C-reactive protein (hs-CRP), and body fat distribution (DXA).
• Assessed serum von Willebrand factor (vWF) levels via ELISA as a marker of endothelial dysfunction.

Main Results:

• Serum vWF levels were significantly higher in both OMN and OMA groups compared to the NMN group.
• The OMA group showed higher vWF levels than the OMN group.
• Android fat mass percentage (AFM%), BMI, and hs-CRP were identified as the primary influencing factors on vWF levels.

Conclusions:

• Endothelial dysfunction is present in obese adults irrespective of their metabolic status.
• A distinct
• healthy obese
• subtype does not appear to exist.
• AFM%, BMI, and hs-CRP are key contributors to endothelial dysfunction in obese individuals.