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Updated: Apr 14, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
Published on: May 10, 2016
Mutagenic and carcinogenic actions of chromium and its compounds
Arstan Abdramanovich Mamyrbaev1, Timur Agataevich Dzharkenov, Zina Amangalievna Imangazina
1West-Kazakhstan State Medical University Named After Marat Ospanov, Maresyev street 68, 030019, Aktobe City, The Republic of Kazakhstan, asemaika@mail.ru.
Abstract:
Numerous experimental observations have been made on microorganisms and culture of the cells of mammals as well as the accounting of the chromosomal aberrations in the bone marrow cells of the mammals and of human cells displayed that the chromium and its compounds possess a pronounced mutagenic effect. Translocation test, induction record of DNA damage and repair systems in the mammalian and human cells with greater precision proves the presence of the mutagenic effect of the chromium and its compounds, which in turn is dependent on dose and time of this metal intoxication. Chromium and its compounds have pronounced mutagenic effect, on increased admission to organism of mammals and protozoa.
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