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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
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Neurological comorbidity and survival in multiple sclerosis
Olga Krökki1, Risto Bloigu2, Hanna Ansakorpi1
1Institute of Clinical Medicine, Neurology, University of Oulu, Oulu, Finland.
Multiple Sclerosis and Related Disorders
|April 17, 2015
Summary
Neurological comorbidities are common in multiple sclerosis (MS) patients, with epilepsy being more prevalent than in the general population. While overall survival is good, stroke negatively impacts survival rates in MS.
Area of Science:
- Neurology
- Epidemiology
Background:
- Multiple sclerosis (MS) survival is of growing interest.
- Comorbid diseases can significantly influence life expectancy in MS patients.
Purpose of the Study:
- To assess the frequency of neurological comorbidities in a population-based multiple sclerosis cohort.
- To analyze the survival rates of these patients.
Main Methods:
- A population-based cohort of 491 patients with clinically definite MS was studied.
- Neurological comorbidities, gender, clinical course, disability (EDSS), and disease duration were evaluated.
- Survival rates were analyzed.
Main Results:
- 17.1% of MS patients had at least one neurological comorbidity.
- Epilepsy prevalence was higher in MS patients (4.7%) compared to the general population.
- Stroke was associated with decreased 21-year survival and increased prevalence with longer MS duration.
Conclusions:
- Neurological comorbidity is common in MS, though only epilepsy showed increased prevalence.
- Peripheral nervous system disorders were linked to primary progressive MS.
- The 21-year survival rate was high, but stroke poses a survival risk.
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