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Updated: Apr 14, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Does glatiramer acetate provoke hepatitis in multiple sclerosis?
Emanuele Sinagra1, Dario Raimondo2, Salvatore Cottone3
1Operative Unit of Internal Medicine, Palermo University, V.Cervello Hospital, Via Trabucco 180, 90146 Palermo, Italy; Endoscopy Unit, Fondazione Istituto San Raffaele - G. Giglio, Cefalù, Italy; PhD course in Surgical Biotechnology and Regenerative Medicine, University of Palermo, Italy.
Abstract:
An association between multiple sclerosis and autoimmune hepatitis has been described. The latter can also be unmasked or exacerbated by a variety of therapies used in multiple sclerosis, such as beta-Interferon or glatiramer acetate. Two cases of hepatitis occurring after exposure to glatiramer acetate are described here: the first, was possibly due to autoimmune hepatitis, rather than glatiramer acetate induced liver injury, the second was definite autoimmune hepatitis. Both occurred in patients who had already experienced hepatitis exacerbations during previous beta-Interferon treatment. We suggest that glatiramer acetate can unmask hepatitis. Thus, liver enzyme monitoring should be undertaken frequently in those patients with multiple sclerosis receiving glatiramer acetate, with a history of hepatitis during treatment with Interferon beta-1a.
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