Related Experiment Video
Updated: Apr 14, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Gamma activity model for treatment-resistant bipolar psychotic mania
Shashi Ranjan Kumar1, Vinod Kumar Sinha1, Sai Krishna Tikka1
1Department of Psychiatry and K. S. Mani Center for Cognitive Neurosciences, Central Institute of Psychiatry, Ranchi, Jharkhand, India.
Objectives:
The objective was to investigate the effect of clozapine on spontaneous gamma activity in treatment-resistant bipolar psychotic mania.
Methods:
Patients with treatment-resistant (TR) bipolar psychotic mania on clozapine monotherapy and nontreatment-resistant bipolar psychotic mania patients receiving lithium were prospectively studied for 6 weeks on severity of psychopathology and 30-49 Hz gamma spectral power.
Results:
Spectral power significantly increased in the lithium group and decreased in the clozapine group; no within group significant difference found.
Conclusions:
We propose a model highlighting the role of gamma spectral power and modulations of GABAergic neurotransmission in TR bipolar psychotic mania.
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