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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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Scrub typhus: Clinical spectrum and outcome
Pradeep M Venkategowda1, S Manimala Rao2, Dnyaneshwar P Mutkule1
1Department of Critical Care Medicine, Yashoda Multi-Speciality Hospital, Somajiguda, Hyderabad, Telangana, India.
Summary
Scrub typhus, a cause of fever and low platelets, can lead to severe Acute Respiratory Distress Syndrome (ARDS). Early doxycycline treatment is crucial for preventing ARDS and improving outcomes in scrub typhus patients.
Area of Science:
- Infectious Diseases
- Pulmonology
- Critical Care Medicine
Background:
- Scrub typhus is a significant differential diagnosis for febrile illness accompanied by thrombocytopenia.
- Acute Respiratory Distress Syndrome (ARDS) in scrub typhus patients is associated with considerable morbidity and mortality.
Purpose of the Study:
- To investigate the clinical characteristics, laboratory findings, and patient outcomes in scrub typhus cases.
- To compare these parameters between scrub typhus patients with and without ARDS.
Main Methods:
- A prospective observational study enrolled 109 patients presenting with fever and thrombocytopenia over 12 months.
- Diagnostic confirmation for scrub typhus involved Immune-chromatography and Weil-Felix tests.
- Clinical data, laboratory values, and outcomes were analyzed using T-tests.
Main Results:
- Of 58 confirmed scrub typhus cases, 34 had no ARDS and 24 had ARDS.
- Patients with ARDS exhibited significant differences in respiratory, hemodynamic, and biochemical markers (P < 0.0001).
- Higher Weil-Felix titers correlated with disease severity; ARDS patients had a mortality rate of 8.3%.
Conclusions:
- Scrub typhus must be considered in patients with fever and thrombocytopenia.
- ARDS significantly increases the severity and mortality risk in scrub typhus.
- Prompt diagnosis and doxycycline administration can avert ARDS development.
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