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Evaluation of nickel complexes of bioligands-effect on distribution profile
R C Srivastava1, S K Srivastava, S Gupta
1Toxicokinetic Division, Industrial Toxicology Research Centre, Lucknow, India.
Research Communications in Chemical Pathology and Pharmacology
|August 1, 1989
Abstract:
Distribution of various nickel-63 bioligand complexes in tissues of rats and their binding to subcellular fractions have been studied. Nickel-binding with glutathione and histidine significantly decreased nickel-63 accumulation while nickel-serum binding increased nickel body burden and its accumulation is subcellular fractions. Nickel-renal cytosol binding exhibited distribution pattern similar to serum complex only in lung tissue.