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Modification of cyclophosphamide-induced urotoxicity by buthionine sulfoximine and disulfiram in mice
M Ishikawa1, Y Takayanagi, K Sasaki
1Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Research Communications in Chemical Pathology and Pharmacology
|August 1, 1989
Abstract:
The effect of buthionine sulfoximine (BSO) and disulfiram (DSF) on the urotoxicity induced by cyclophosphamide (CPA) was examined in mice. Pretreatment of mice with BSO (500 mg/kg, i.p.) 5 hr prior to CPA resulted in enhanced urotoxicity of CPA. In contrast, simultaneous administration of DSF (200 mg/kg, p.o.) decreased the urotoxicity of CPA.