Antigenic heterogeneity in granular cell ameloblastoma: an immunohistochemical study
Related Experiment Video
Updated: Apr 14, 2026
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
Published on: May 17, 2024
Ramadoss Ramya1, Peddanna Kondamari Sudheerkanth2, Cherian Eapen3
1Reader, Department of Oral Pathology, SRM Dental College, Chennai, Tamil Nadu, India.
Background:
Nature of granular cells in granular cell ameloblastoma (GCA) has always invoked considerable interest. The present study aims at antigenic characterization in five such cases with a panel of markers.
Materials And Methods:
Tissue specimens of five patients with GCA were fixed in buffered formalin and later embedded in paraffin wax. Blocks were sliced into 3 µ thick sections for immunohistochemical analysis using a panel of markers CD68, Bcl2, S100, p53, cytokeratin (AE1/AE3), vimentin and desmin.
Results:
All five cases were strongly positive for cytokeratin and CD68. S100 was negative in three cases and showed a mild positivity in two cases. Bcl2, p53, vimentin and desmin were negative in all the five cases.
Conclusions:
This study presents a heterogenous nature of the granular cells; however, further validation is required with a larger sample size.
Related Concept Videos
01:30Classification of Leukocytes
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
01:26Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and...