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Predictive value of elevated neutrophil-lymphocyte ratio for left ventricular systolic dysfunction in patients with

Adem Bekler1, Gokhan Erbag2, Hacer Sen3

  • 1Adem Bekler, MD, Department of Cardiology, Canakkale Onsekiz Mart University, School of Medicine, Canakkale/Turkey.

Pakistan Journal of Medical Sciences
|April 17, 2015
PubMed

Insights

A high neutrophil-lymphocyte ratio (NLR) predicts left ventricular systolic dysfunction (LVSD) in non ST-elevated acute coronary syndrome (NSTE-ACS) patients. Admission NLR >3.2 identifies high-risk individuals needing tailored treatment strategies.

Area of Science:

  • Cardiology
  • Hematology
  • Biomarkers

Background:

  • Non ST-elevated acute coronary syndrome (NSTE-ACS) is a common cardiac emergency.
  • Left ventricular systolic dysfunction (LVSD) is a significant complication impacting patient outcomes.
  • Identifying early predictors of LVSD in NSTE-ACS is crucial for timely intervention.

Purpose of the Study:

  • To investigate the predictive value of the neutrophil-lymphocyte ratio (NLR) for LVSD in NSTE-ACS patients.
  • To determine if admission NLR can identify patients at higher risk of developing LVSD.

Main Methods:

  • A cohort of 405 NSTE-ACS patients was analyzed.
  • Patients were stratified into tertiles based on admission NLR values (low ≤1.81, medium 1.81-3.2, high >3.2).
  • Multivariate analyses were performed to identify independent predictors of systolic dysfunction.

Main Results:

  • The high NLR group (NLR >3.2) exhibited older age, higher rates of diabetes and NSTEMI, and lower left ventricular ejection fraction (LVEF).
  • NLR was negatively correlated with LVEF.
  • An NLR >3.2 and age ≥70 were independent predictors of systolic dysfunction.

Conclusions:

  • An admission NLR >3.2 is a valuable predictor of LVSD in NSTE-ACS patients.
  • Utilizing NLR on admission can aid in identifying high-risk patients.
  • This may guide the selection of appropriate treatment strategies for these patients.
Abstract

Keywords:
Acute coronary syndromeEjection fractionMyocardial infarctionNeutrophil-lymphocyte ratioSystolic dysfunction

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