Isolated central nervous system relapse in chronic myeloid leukemia
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Updated: Apr 14, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
Juliana Gomez1, Victor Duenas2
1Internal Medicine Department, Guillermo Almenara Irigoyen National Hospital, Grau Avenue 800, Lima, Peru.
Abstract:
Chronic myeloid leukemia is a myeloproliferative disorder that has three distinguished phases: chronic, accelerated, and blastic. In extremely rare cases, the blast phase can affect the central nervous system without concomitant bone marrow involvement. We report the case of a patient with chronic myeloid leukemia who, despite having achieved complete cytogenetic remission in the bone marrow for several years, experienced a blast crisis of the central nervous system following an episode of infectious meningoencephalitis.
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