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Related Experiment Video

Updated: Apr 14, 2026

Two-photon Imaging of Cellular Dynamics in the Mouse Spinal Cord

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Recurrent tumefactive demyelination: An unusual presentation.

Amita Bhargava¹, Guruprasad S Pujar¹, Basavaraj F Banakar¹

¹Department of Neurology, Dr. S. N. Medical College, Jodhpur, Rajasthan, India.

Journal of Pediatric Neurosciences

|April 17, 2015

Summary

Tumefactive demyelination, a rare MS variant, presents as large brain lesions. This case highlights a unique, recurrent presentation in a young girl, emphasizing diagnostic challenges.

Keywords:

Demyelination multiple sclerosis tumefactive

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Area of Science:

Neurology
Radiology

Background:

Tumefactive multiple sclerosis (MS) is a rare demyelinating condition.
Characterized by large lesions (>2 cm) on MRI, it mimics intracranial space-occupying lesions.
Accurate diagnosis is crucial to prevent unnecessary interventions.

Observation:

A 14-year-old female presented with recurrent subacute hemiparesis over 6 months.
Brain MRI revealed large T2/FLAIR hyperintense lesions with incomplete ring enhancement.
Minimal surrounding edema and mass effect were noted.

Findings:

The patient was diagnosed with tumefactive demyelination (TD).
Treatment with steroids led to recovery with minimal deficits.
This recurrent presentation in a young girl is unprecedented.

Implications:

Highlights the importance of considering TD in young patients with large intracranial lesions.
Emphasizes the diagnostic challenge posed by tumefactive lesions.
Suggests potential for recurrent TD even in young individuals.