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Related Experiment Videos

[Osteoporosis: a case report].

T Strack, J Beyer, P Kann

    Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse De Medecine Praxis
    |November 21, 1989
    PubMed
    Summary
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    Severe osteoporosis and multiple fractures in a 56-year-old female were linked to undiagnosed endogenous hypercortisolism caused by a pituitary microadenoma. Surgical removal resolved the condition, highlighting the importance of investigating hormonal imbalances in osteoporosis.

    Area of Science:

    • Endocrinology
    • Bone Metabolism
    • Neurosurgery

    Background:

    • Osteoporosis is a significant public health concern, characterized by low bone mass and microarchitectural deterioration.
    • Idiopathic osteoporosis, particularly low-turnover osteoporosis, necessitates investigation into underlying causes beyond typical risk factors.

    Observation:

    • A 56-year-old female presented with severe osteoporosis and recurrent spontaneous fractures, including vertebral compression fractures.
    • Clinical signs of hypercortisolism were absent, yet biochemical tests revealed attenuated diurnal cortisol variation and lack of suppressibility.
    • Radiological imaging identified a pituitary microadenoma.

    Findings:

    • Histological examination confirmed low-turnover osteoporosis.
    • Endogenous hypercortisolism, secondary to a pituitary microadenoma, was identified as the cause of the patient's severe osteoporosis.

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  • Transsphenoidal surgery successfully removed the pituitary adenoma.

    • Implications:

    • This case underscores the importance of considering endogenous hypercortisolism in patients with severe, unexplained osteoporosis, even in the absence of classic clinical signs.
    • Early diagnosis and surgical intervention for pituitary adenomas can effectively manage secondary osteoporosis.
    • Highlights the interplay between endocrine disorders and bone health, necessitating a multidisciplinary approach to diagnosis and treatment.